Comprehensive Natural Products II: Chemistry and Biology: by Lewis Mander, Hung-Wen Liu

By Lewis Mander, Hung-Wen Liu

This paintings offers a definitive interpretation of the present prestige of and destiny developments in average products-a dynamic box on the intersection of chemistry and biology curious about isolation, id, constitution elucidation, and chemical features of certainly happening compounds similar to pheromones, carbohydrates, nucleic acids, and enzymes. With greater than 1,800 colour figures, accomplished typical items II beneficial properties a hundred% new fabric and enhances instead of replaces the unique paintings (©1999).* stories the amassed efforts of chemical and organic study to appreciate residing organisms and their particular results on future health and drugs * Stimulates new rules one of the demonstrated ordinary items learn community-which contains chemists, biochemists, biologists, botanists, and pharmacologists * Informs and conjures up scholars and novices to the sector with obtainable content material in various supply codecs  

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Additional resources for Comprehensive Natural Products II: Chemistry and Biology: Amino Acids, Peptides and Proteins

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96 Generally, most of the nonprotein amino acids containing aryl or functionalized aryl side chains are part of nonribosomal peptides isolated from bacteria, fungi, and sponges. These peptides exhibit interesting biological activities that include antimicrobial, antitumor, antifungal, and other inhibitory activities. Table 3 describes many of these types of amino acids. 4 Amino Acids with Amino Groups as Part of the Side Chain This section focuses on those nonprotein amino acids that contain amino groups in the side chain.

13 The hydroxylation is carried out by trimethyllysine dioxygenase, a nonheme FeII-dependent enzyme that uses O2 and 2-oxoglutarate as substrates. 192 These amino acids have polyhydroxylated long lipid chains and exhibit antifungal properties. 194 Fluorinated amino acids present another interesting class of halogenated nonprotein amino acids. 195 Table 5 also contain nonprotein amino acids that have halide or thiol groups in addition to hydroxyl groups on their side chains. 6 Amino Acids with Carbonyl Groups as Part of the Side Chain There is only a small selection of nonprotein amino acids that contain carbonyl groups in the form of ketone, aldehyde, and carboxylic acid moieties, as part of the side chain.

Lincomycin and clindamycin – broad spectrum antibiotics (lincosamides) 242, 243 Isolated from Streptomyces sp. Chloptosin – dimeric nonribosomal peptide with apoptosis-inducing activity A83586 – peptide-based antibiotic 244 O N H CO2H CO2H N H CO2H N H 241 CO2H N H CO2H N H CO2H N H N CO2H R Lincomycin B – peptide antibiotic (N-methyl-4ethylproline) R = H, Me N CO2H Me HN N H CO2H 245 (Continued ) Nonprotein L-Amino Acids 53 Table 7 (Continued) Structure S N H Biological origin Biological properties References Algea – Heterochordaria abietina No known bioactivity 217 Blue-green algae – Anabaena laxa Marine sponge – Callyspongia abnormis Laxaphycins A and E – antifungal peptides Callynormine A – no bioactivity has been reported 246–248 Bacteria – Streptomyces sp.

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