DEVELOPMENTAL PSYCHOPATHOLOGY. Developmental Neuroscience by DANTE CICCHETTI

By DANTE CICCHETTI

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Courchesne, 1997), as well as other cortical and subcortical regions as fundamental to the etiology of Autism. Until recently, etiological formulations of Autism have failed to take into account the impact of developmental processes and the probable interconnected nature of multiple brain systems at multiple levels of analysis. Many of the conceptualizations of neural-structural abnormalities underlying the behavioral manifestations of Autism have been based on data obtained through neuropsychological assessment of children with Autism.

Courchesne, 1997), as well as other cortical and subcortical regions as fundamental to the etiology of Autism. Until recently, etiological formulations of Autism have failed to take into account the impact of developmental processes and the probable interconnected nature of multiple brain systems at multiple levels of analysis. Many of the conceptualizations of neural-structural abnormalities underlying the behavioral manifestations of Autism have been based on data obtained through neuropsychological assessment of children with Autism.

Rather, the findings suggest that an increasing number of diverse phenotypic signs emerge with age as the various brain systems required for their expression reach fundamental maturity. Finally, because similar functional disturbances were observed in the unaffected siblings of the preschizophrenic cases, it would appear that these cognitive, motor, and behavioral disturbances are indicators of an inherited neural diathesis to Schizophrenia (cf. Walker & Diforio, 1997). In addition to the early and more recent work with preschizophrenic infants and children that served as an impetus for modifying the Kraepelinian (1919) view of Schizophrenia, contemporary findings have contributed to the belief that the neurobiological foundations of Schizophrenia are established, at least in part, during the development of the brain.

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