Handbook of Molecular Force Spectroscopy by Noy A. (ed.)

By Noy A. (ed.)

Smooth fabrics technology and biophysics has more and more interested by learning and controlling intermolecular interactions at the single–molecule point. The peer–reviewed literature comprises progressively more stories that both degree the interplay forces at once or use mechanical forces to deform the molecules or set off structural transitions. Molecular strength spectroscopy is the results of extraordinary advances within the services of contemporary strength dimension tools some time past decade and describes a few recommendations that use mechanical strength measurements to check interactions among unmarried molecules and molecular assemblies in chemical and organic structures. Examples of those suggestions contain atomic strength microscopy, optical tweezers, floor forces equipment, and magnetic tweezers. those strategies more often than not aim a particular diversity of experimental platforms and geometries, yet all use mechanical strength transducers to use and realize nanonewton diversity forces among unmarried molecules in condensed stages.

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Extra resources for Handbook of Molecular Force Spectroscopy

Sample text

Ashkin went on to pioneer optical trapping of both atoms and biomolecules, leading to one of the most successful technology transfers from a physics lab to cell biology. For many applications, in particular for characterizing biomolecules and their interactions, it is desirable to have a non-contact technique for exerting a force. A non-contact technique allows the behavior of a single molecule under stretching or torsional forces to be measured and manipulated without complicating surface effects or material response limitations.

A non-contact technique allows the behavior of a single molecule under stretching or torsional forces to be measured and manipulated without complicating surface effects or material response limitations. Non-contact techniques also benefit from being easier to multiplex into exerting force on multiple sites of the same molecule or multiple heterogeneous molecules, or to collect parallel statistics on homogeneous copies of the same system. In general they are not limited by access constraints to the interaction volume, and therefore integrate more readily with the desired environmental conditions and other imaging and spectroscopic techniques.

These traps can be inexpensively microfabricated and used to characterize and trap a wide variety of molecules, cells, and particles [7]. Although terahertz [8] and mid-infrared [9] frequencies are used for spectroscopy, they have not been used for detecting and trapping single biomolecules, providing a clear distinction between the low frequency electrode traps and the purely optical, high frequency traps. Although the higher optical frequencies provide the greatest intensity and the smallest trapping volumes, terahertz and mid-infrared tweezers may have advantages in addressing specific bonds and in cell characterization.

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