Introduction to Mechanisms of Hormone Action by P. Catherine Clegg

By P. Catherine Clegg

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However the movement of glucose from the interstitial fluid into the cells seems to depend upon a special mechanism located in the cell membrane. This is a system of active transport of sugar molecules across the membrane. It is suggested that the membrane contains a substance called a carrier which is capable of entering into a reversible combination with glucose. It is supposed that the carrier is capable of oscillating or diffusing across the cell memĀ­ brane and that association with the carrier at the outer surface of the cell membrane and disassociation from it at the internal surface of the membrane is the only way in which glucose can cross the cell membrane.

Diagram showing typical structure of a chromaffine cell, The chromaffine granules containing the hormone appear to arise in the Golgi apparatus. The membrane bound granules are shown approaching the cell membrane where the two membranes appear to fuse releasing the contents which finally reach the lumen of blood capillaries. Note the "patchy" nature of the capillary wall adjacent to the secreting cell, facilitating the diffusion of the hormone into the bloodstream. 42 Mechanisms of Hormone Action nerves.

A large number of metabolic processes have been found to be influenced by this nucleotide and include the transport of sugar by epithelial cells of the thyroid gland, water permeability of toad bladder, synthesis of liver proteins and steroid hormones. Various enzyme systems are also activated by the nucleotide. 3',5'-AMP obviously is of wide significance in the regulation of metabolic processes. Moreover the action of the hormone adrenaline on the synthesis of 3',3'-AMP is by no means specific.

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