Rang and Dale's Pharmacology (6th Edition) by M. M. Dale, J. M. Ritter, R. J. Fowler, H. P. Rang

By M. M. Dale, J. M. Ritter, R. J. Fowler, H. P. Rang

Rang & Dale's Pharmacology offers you all of the wisdom you want to get via your pharmacology path and past. Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson current a transparent and obtainable method of the research of healing brokers on the mobile and molecular point via specific diagrams, full-color illustrations, and pedagogical gains. Plus, USMLE-style overview questions and extra studying instruments on-line at studentconsult.com make this definitely the right source to show to for an entire realizing of key strategies in pharmacology.

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Extra resources for Rang and Dale's Pharmacology (6th Edition)

Sample text

The right, without any change in slope or maximum—the hallmark of competitive antagonism (Fig. 4A). The shift is expressed as a dose ratio, r, (the ratio by which the agonist concentration has to be increased in the presence of the antagonist in order to restore a given level of response). Theory predicts that the dose ratio increases linearly with the concentration of the antagonist (see p. 17). These predictions are often borne out in practice (see Fig. 5), and examples of competitive antagonism are very common in pharmacology.

Classical approaches to the study of drug–receptor interactions. , Johansen, T. ), Textbook of Receptor Pharmacology. CRC Press, Boca Raton. , 1997. Pharmacologic analysis of drug–receptor interactions, third ed. Lippincott-Raven, New York. , 2003. International Union of Pharmacology Committee on receptor nomenclature and drug classification: XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol. Rev. 55, 597–606. , 2006. The receptor concept: Pharmacology’s Big Idea. Br.

9) Thus rA depends only on the concentration and equilibrium constant of the competing drug B, not on the concentration or equilibrium constant of A. 17 2 SECTION 1 GENERAL PRINCIPLES If A is an agonist, and B is a competitive antagonist, and we assume that the response of the tissue will be an unknown function of pA, then the value of rA determined from the shift of the agonist concentration–effect curve at different antagonist concentrations can be used to estimate the equilibrium constant KB for the antagonist.

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