By Atta-ur-Rahman (Eds.)
Natural items within the plant and animal country provide an incredible variety of chemical buildings which are the results of biosynthetic tactics which have been modulated over the millennia via genetic results. With the quick advancements in spectroscopic recommendations and accompanying advances in high-throughput screening strategies, it has turn into attainable to isolate after which ascertain the constructions and organic job of common items swiftly, therefore commencing up fascinating new possibilities within the box of recent drug improvement to the pharmaceutical undefined.
The sequence additionally covers the synthesis or trying out and recording of the medicinal houses of common products.
- Describes the chemistry of bioactive ordinary products
- Contains contributions by means of top experts within the field
- A necessary source for usual items and medicinal chemistry
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Additional resources for Studies in Natural Products Chemistry, Volume 41
Example text
128 (2010) 615–622. [45] P. Lan, J. M. Zhang, C. H. H. M. C. M. Chen, Eur. J. Med. Chem. 46 (2011) 2490–2502. C. A. Salvador, S. Marı´n, M. N. C. Dinis, Bioorg. Med. Chem. 18 (2010) 4385–4396. [47] H. N. Kaluđerovic´, K. Jutta, R. Paschke, Invest. New Drugs 29 (2011) 266–272. [48] H. N. Kaluderovic´, M. Bette, J. Kalbitz, P. Fuchs, S. Fulda, W. Mier, R. Paschke, Chem. Biol. Interact. 185 (2010) 128–136. 32 Studies in Natural Products Chemistry [49] R. Csuk, A. Barthel, S. Schwarz, H. Kommera, R.
Compound 62 (Fig. 13) was able to induce apoptosis in HT-29 cancer cells [210]. Glycidic amide 63 (Fig. 5 mM, b-keto esters 64 and 65 (Fig. 7 mM, respectively, in a series of cancer cell lines [183]. Compound 66 (Fig. 6 mM with the ability to induce apoptosis through activation of caspases 9, 7, and 3 [211]. BA derivative 67 (Fig. 14) inhibited tumor growth in mice transplanted with LNCaP cancer cells. This derivative presented high solubility in aqueous OH R2 O RO R1O R1 R 61 COC6H4(3-)CF3 63 62 COCH2Cl Ac 64 Ac 65 OMe 66 R2 CONEt2 O CO2Et O CO2Et O OMe CH2OH O OH H2N FIGURE 13 BA 2 derivatives 61–66.
185 (2010) 128–136. 32 Studies in Natural Products Chemistry [49] R. Csuk, A. Barthel, S. Schwarz, H. Kommera, R. Paschke, Bioorg. Med. Chem. 18 (2010) 2549–2558. [50] R. Csuk, A. Barthel, R. Kluge, D. Stro¨hl, H. Kommera, R. Paschke, Bioorg. Med. Chem. 18 (2010) 1344–1355. [51] R. Csuk, A. Barthel, R. Kluge, D. Stro¨hl, Bioorg. Med. Chem. 18 (2010) 7252–7259. C. A. Salvador, R. Corte´s, G. Pacho´n, S. Marı´n, M. Cascante, Biochimie 93 (2011) 1065–1075. [53] Z. Lu, Y. Jin, C. Chen, J. Li, Q. Cao, J.