The Actions and Uses of Ophthalmic Drugs. A Textbook for by P. H. O'Connor Davies

By P. H. O'Connor Davies

The collaboration among pharmacologist and optometrist has produced a piece which supplies a theoretical foundation for the appliance of substances, an emphasis on care and discrimination within the use of substances, and assistance on many key functional matters similar to using mydriatic and miotic brokers. This new version takes account of the advancements that have taken position in pharmaceutical technological know-how and optometric perform over the last few years: a finished survey is given of contemporary touch lens arrangements; there's a concise define of advancements in medications utilized by ophthalmologists which are appropriate to optometry; a overview of ocular antagonistic reactions to systemic and topical medicinal drugs which should still support the optometrist within the detection, administration and reporting of those stipulations; readers could be brought to the foundations of using healing medications, now already a characteristic of optometric perform in lots of components of america. A bankruptcy on microbiology has been incorporated as the introduction of ailments reminiscent of AIDS and acanthamoeba has highlighted a demand for a few wisdom during this region

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Figure 2. J-Antero-posterior section through the anterior portion of the eye. The radial, meridional and circular fibres shown are of the ciliary muscle (after Wolff' Anatomy of the Eye and Orbit. London; H. K. Lewis) Parasympathetic innervation of the eye 21 22 Ocular autonomic innervation and neurohumoral transmission brain in the main trunk of the third nerve, which, just before entering the orbit, divides into superior and inferior divisions. The parasympathetic fibres continue in the inferior division and pass into its inferior obhque branch, which they leave to form the motor root of the ciliary ganglion.

In the past, histochemical and electron microscopical studies have thrown doubt on this theory, although clinical observations appear to support it. More recently, work by Van Alpen (1976), using material obtained from eye banks, showed that the ciliary muscle has mostly /^-receptors, the dilatator pupillae muscle mostly or-receptors, and the sphincter pupillae muscle has both a- and yff-receptors. Adrenergic impulses to the intra-ocular muscles should, therefore, simultaneously induce relaxation of the ciliary muscle, contraction of the dilatator pupillae and have an uncertain response to the sphincter pupillae.

Biol. Chem. 170, 545-550 H O D G K I N . A. L. and H U X L E Y . A. F. (1952). ' J. , Lond. 117, 500-544 K A T Z . B. (1966). Nerve, Muscle and Synapse, New York: McGraw-Hill . I R . (1965). T h e measurement of synaptic delay, and the time course of K A T Z , B. and M I L E D acetylcholine release at the neuromuscular j u n c t i o n . ' Proc. R. Soc. B. 161, 483-495 K A T Z . B. and M I L E D. I R . (1972). T h e statistical n a t u r e of acetylcholine potential and its molecular c o m p o n e n t s .

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